Dra. Sonia Tejada Solís

 Experiencia profesional

• Más de 20 años de experiencia
• Médico especialista en Medicina Estética en la Clínica Fercasy (Actualidad)
• Médico especialista en Neurocirugía en el Hospital Fundación Jiménez Díaz (2019-Actualidad)
• Médico especialista en Neurocirugía en el Hospital Ruber Internacional (2019-Actualidad)
• Consultora en Neurocirugía en el Departamento de Neurocirugía clínica en la Universidad de Navarra (2007-2019)

...

 Subespecialización

• Neurooncología quirúrgica
• Neuralgia del trigémino

 Docencia

• Profesora por la ANECA (2012-Actualidad)
• Profesora asociada de la Universidad de Navarra (2007-2019)

 Logros académicos destacados

• Licenciada en Medicina y Cirugía por la Universidad de Navarra (2001)
• Doctorado por la Universidad de Alcalá de Henares (2007)
• Rotación externa de Neurocirugía oncológica en el MD Anderson (2005)
• Rotación externa de Neurocirugía pediátrica en el Hospital 12 de Octubre (2006)
• ​Médico interno residente en la especialidad de Neurocirugía en el Hospital Ramón y Cajal (2002-2007)
• Estancia en el King Edward Memorial Hospital en Mumbai (2015)
• Fellowship de Neurocirugía pediátrica e imagen intraoperatoria en el Hospital Alder Hey, Liverpool (2015)
• Rotación externa en cirugía endoscópica en el John Radcliffe Hospital, Oxford (2016)
• Rotación externa en cirugía de epilepsia pediátrica en el Hospital Alder Hey, Liverpool (2019)

...

 Publicaciones y conferencias

• The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models Nat Commun. 2019;
• Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma. Nat Med. 2019
• Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors. Cancers (Basel). 2018
• The impact of intraoperative magnetic resonance in routine pediatric neurosurgical practice-a 6-year appraisal. Childs Nerv Syst. 2018
• Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma. J Clin Oncol. 201
• DNX-2401, an Oncolytic Virus, for the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Gliomas: A Case Report. Front Oncol. 2018
• The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma.Neuro Oncol. 2018
• Intraoperative 3 tesla magnetic resonance imaging: our experience in tumors. Radiologia. 2018
• Phase I Trial of DNX-2401 for Diffuse Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients. Neurosurgery. 2017
• Results of a Policy of Fast Tapering of Steroids After Resection Surgery in Glioblastoma. World Neurosurg. 2018
• 3D printing in neurosurgery: a specific model for patients with craniosynostosis. Neurocirugia (Astur). 2017
• A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients. J Transl Med. 2017
• Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System. PLoS One. 2017
• Safety Profile of 5-Aminolevulinic Acid as a Surgical Adjunct in Clinical Practice: A Review of 207 Cases From 2008 to 2013. J Neurosurg Anesthesiol. 2015
• A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol. 2014 Apr;16(4):520-7.
• Factors associated with a higher rate of distant failure after primary treatment for glioblastoma. J Neurooncol. 2014
• Involvement of miRNAs in the Differentiation of Human Glioblastoma Multiforme Stem-Like Cells. PLoS One. 2013
• Prognostic Value of Residual Fluorescent Tissue in Glioblastoma Patients After Gross Total Resection in 5-ALA Guided Surgery. Neurosurgery. 2013
• Dendritic cell vaccination in glioblastoma after fluorescence guided resection. World J clinical Oncol. 2012
• Prognostic value of ventricular wall fluorescence during 5-aminolevulinic-guided surgery for glioblastoma.Acta Neurochir (Wien). 2012
• Genetic and epigenetic modifications of Sox2 contribute to the Invasive phenotype of malignant gliomas. PLos One 6(11). Epub 2011
• Quantitative volumetric analysis of gliomas with sequential MRI and (11)C-methionine PET assessment: patterns of integration in therapy planning. Eur J Nucl Med Mol Imaging. 2012
• Voxel-based analysis of dual-time-point 18F-FDG PET images for brain tumor identification and delineation. J Nucl Med. 2011
• Surgery guided by 5-aminolevulinic fluorescence in glioblastoma: volumetric analysis of extent of resection in single-center experience. J Neurooncol. 2011
• Eukaryotic initiation factors (eIF) 2alpha and 4E expression, localization and phosphorilation in brain tumors. J Histochem Cytochem. 2009
• CONFERENCIAS: Gross Total Resection in a Glioblastoma following the border of the tumor with 5-ala fluorescence guiadance (WFNS, Boston 2009) Utility of PET-methionine in diagnosis and treatment of brain tumors (SENEC, A Coruña, 2010) Prognostic value of ventricular wall fluorescence during 5-aminolevulinic-guided surgery for glioblastoma. (SENEC, Las Palmas 2012) Fluorescence guided surgery and its application in research (Chinese Neurosurgeon Society, Hangzhou, 2012) Prognostic Value of Residual Fluorescent Tissue in Glioblastoma Patients after Gross Total Resection in 5-ala Guided Surgery (WFNS, Seul 2013) Ensayo clínico con virus oncolítico en el tratamiento del glioblastoma: Datos de los primeros pacientes tratados (SENEC Cadiz, 2014) Phase I Trial of combination of DNX-2401 (formerly named Delta-24-RGD) oncolytic adenovirus with a short course of temozolomide for treatment of glioblastoma at first recurrence (Poster, oral presentation SNO, Miami 2014) Clinical trial: oncolityc virus DNX-2401 in glioblastoma recurrence (International Neurooncology Meeting, Cortona, Italy June 2015) Recidiva vs radionecrosis, la utilidad del PET y las secuencias avanzadas de resonancia y su correlación con la histología. Papel de la cirugía (reunión del grupo de tumores de la SENEC, Miraflores 7 abril 2016) Lessons learnt with the intraoperative magnetic resonance in a pediatric neurosurgical unit after 5 years (SENEC, Estoril, 12 mayo 2016). A Phase I study of the oncolytic virus DNX-2401 and a short course temozolomide for glioblastoma (SNO annual meeting, Phoenix, Nov 2016) Intraoperative MRI, when to use it? (Hannover, 24 Febrero 2017) Experience with high field intraoperative MRI in brain tumor surgery. SENEC 2017 Barcelona Evaluación de los hallazgos radiológicos en la resonancia intraoperatoria para la cirugía cerebral. SENEC 2018 Toledo Gliomas difusos de protuberancia: estado actual y presentación de un ensayo clínico con virus oncolíticos. SENEP San Sebastián, 2018. Oncolytic virus for DIPG: a clinical trial. ESPN 2018 Bonn Experience with the Intraoperative Magnetic Resonance in pediatric brain tumor surgery and Oncolytic Virus for pediatric HGG and DIPG: from the bench to thebedside. ISPNO 2018 Denver. New Cannula For Brain Delivery Drugs, Experience With Oncolytic Virus Infusion For DIPG. WFNS meeting 2018. Experience With Oncolytic Virus Infusion For DIPG. Washington 2018 New strategies in the treatment of pediatric High grade gliomas: a neurosurgical point of view. Masterclass Liverpool 2018 Phase I clinical trial with oncolytic virus DNX-2401 for DIPG. EANO, Lyon 2019

...

 Premios y reconocimientos

• Segundo Sexenio de Investigación (2013-2018)
• Primer Sexenio de Investigación (2007-2012)
• Suma Cum Laude en la defensa de la tesis doctoral (2007)
• Premio por la Sociedad Española de Neurocirugía a la mejor rotación externa (2005)

...

 Miembro de asociaciones médicas privadas

• Miembro de la Sociedad Española de Neurocirugía (SENEC)
• Miembro de la Sociedad Española de Neurocirugía pediátrica (SENEP)
• Miembro de la Sociedad Europea de Neurooncología
• Miembro Internacional de la Asociación Americana de cirugía neurológica
• Miembro de la Sociedad de Neurooncología

...